Structure of PDB 3wwm Chain A

Receptor sequence
>3wwmA (length=269) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence]
MIVVKVGGAEGINYEAVAKDAASLWKEGVKLLLVHGGSAETNKVAEALGH
PPRFLTHPGGQVSRLTDRKTLEIFEMVYCGLVNKRLVELLQKEGANAIGL
SGLDGRLFVGRRKTAVKYVENGKVKVHRGDYTGTVEEVNKALLDLLLQAG
YLPVLTPPALSYENEAINTDGDQIAALLATLYGAEALVYLSNVPGLLARY
PDEASLVREIPVERIEDPEYLALAQGRMKRKVMGAVEAVRGGVKRVVFAD
ARVENPIRRALSGEGTVVR
3D structure
PDB3wwm Structural insight into amino group-carrier protein-mediated lysine biosynthesis: crystal structure of the LysZ·LysW complex from Thermus thermophilus.
ChainA
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) K5 G8 S38 D172 K231
Catalytic site (residue number reindexed from 1) K5 G8 S38 D172 K231
Enzyme Commision number 2.7.2.17: [amino-group carrier protein]-L-2-aminoadipate 6-kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ADP A G8 G36 G37 S38 Y78 Y200 M228 G8 G36 G37 S38 Y78 Y200 M228
Gene Ontology
Molecular Function
GO:0003991 acetylglutamate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0043744 N2-acetyl-L-aminoadipate kinase activity
Biological Process
GO:0006526 L-arginine biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0016310 phosphorylation
GO:0019878 lysine biosynthetic process via aminoadipic acid
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wwm, PDBe:3wwm, PDBj:3wwm
PDBsum3wwm
PubMed25392000
UniProtO50147|LYSZ_THET2 [LysW]-aminoadipate kinase (Gene Name=lysZ)

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