Structure of PDB 3wuh Chain A

Receptor sequence
>3wuhA (length=344) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
KGYKVLAIETSCDDTCVSVLDRFSKSAAPNVLANLKDTLDKAHIHHQARI
GPLTERALIESNAREGIDLICVTRGPGMPGSLSGGLDFAKGLAVAWNKPL
IGVHHMLGHLLIPRMGTNGKVPQFPFVSLLVSGGHTTFVLSRAIDDHEIL
CDTIDIAVGDSLDKCGRELGFKGTMIAREMEKFINQDINDQDFALKLEMP
RNMLSFSFSAFITALRTNLTKLGKTPEREIRSIAYQVQESVFDHIINKLK
HVLKSQPEKFKNVREFVCSGGVSSNQRLRTKLETELFNFYYPPMDLCSDN
SIMIGWAGIEIWESLRLVSDLDICPIRQWPLNDLLSVDGWRTDQ
3D structure
PDB3wuh Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP
ChainA
Resolution2.937 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.1.234: N(6)-L-threonylcarbamoyladenine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H145 H149 H175 D361 H105 H109 H135 D299
BS02 AMP A S172 G173 G199 D203 M215 A217 R218 E221 G325 S328 N329 S360 S132 G133 G159 D163 M175 A177 R178 E181 G271 S274 N275 S298
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0008252 nucleotidase activity
GO:0008270 zinc ion binding
GO:0016746 acyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups
GO:0046872 metal ion binding
GO:0061711 N(6)-L-threonylcarbamoyladenine synthase activity
Biological Process
GO:0002949 tRNA threonylcarbamoyladenosine modification
GO:0006400 tRNA modification
GO:0008033 tRNA processing
GO:0070525 tRNA threonylcarbamoyladenosine metabolic process
GO:0072670 mitochondrial tRNA threonylcarbamoyladenosine modification
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wuh, PDBe:3wuh, PDBj:3wuh
PDBsum3wuh
PubMed25084372
UniProtP43122|QRI7_YEAST tRNA N6-adenosine threonylcarbamoyltransferase, mitochondrial (Gene Name=QRI7)

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