Structure of PDB 3wt5 Chain A

Receptor sequence
>3wt5A (length=240) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLADLV
SYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDM
SWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLM
AICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMI
QKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB3wt5 A Mixed Population of Antagonist and Agonist Binding Conformers in a Single Crystal Explains Partial Agonism against Vitamin D Receptor: Active Vitamin D Analogues with 22R-Alkyl Group.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 S252 I256 K260 P412 E416 I58 K62 S72 I76 K80 P232 E236
BS02 YA1 A Y143 V230 S233 I264 R270 S271 S274 W282 C284 H301 L309 H393 F418 Y21 V50 S53 I84 R90 S91 S94 W102 C104 H121 L129 H213 F238 MOAD: ic50=0.29nM
PDBbind-CN: -logKd/Ki=9.54,IC50=0.29nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3wt5, PDBe:3wt5, PDBj:3wt5
PDBsum3wt5
PubMed24742174
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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