Structure of PDB 3wsz Chain A

Receptor sequence
>3wszA (length=561) Species: 9606 (Homo sapiens) [Search protein sequence]
EPIKVYGQVSLNDSHNQMVVHWAGEKSNVIVALARDSLPKSSDVYVSYDY
GKSFKKISDKLNFGLGNRSEAVIAQFYHSPADNKRYIFADAYAQYLWITF
DFCNTLQGFSIPFRAADLLLHSKASNLLLGFDRSHPNKQLWKSDDFGQTW
IMIQEHVKSFSWGIDPYDKPNTIYIERHEPSGYSTVFRSTDFFQSRENQE
VILEEVRDFQLRDKYMFATKVVHLLGSLWVSFGRKPMRAAQFVTRHPINE
YYIADASEDQVFVCVSHSNNRTNLYISEKFSLSLENVLYYSPGGAGSDTL
VRYFANEPFADFHRVEGLQGVYIATLINGNMRSVITFDKGGTWEFLQAPA
FTGKINCELSQGCSLHLAQRLSQLLNLQLRRMPILSKESAPGLIIATGSV
GKNLASKTNVYISSSAGARWREALPGPHYYTWGDHGGIITAIAQGMETNE
LKYSTNEGETWKTFIFSEKPVFVYGLLTEPGEKSTVFTIFGSNKENVHSW
LILQVNATDALGVPCTENDYKLWSPSDERGNECKTVFKRRTPHATCFNGE
DFDRPVVVSNC
3D structure
PDB3wsz Structural basis for amyloidogenic peptide recognition by sorLA.
ChainA
Resolution3.201 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A N103 Q104 M105 V106 V107 R490 Y584 H608 N16 Q17 M18 V19 V20 R380 Y474 H498
Gene Ontology

View graph for
Cellular Component
External links
PDB RCSB:3wsz, PDBe:3wsz, PDBj:3wsz
PDBsum3wsz
PubMed25643321
UniProtQ92673|SORL_HUMAN Sortilin-related receptor (Gene Name=SORL1)

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