Structure of PDB 3wsb Chain A

Receptor sequence
>3wsbA (length=341) Species: 353153 (Trypanosoma cruzi strain CL Brener) [Search protein sequence]
DEDLRFCYDILQAVSRSFAVVIMELDEEMRDAVCIFYLVLRALDTVEDDM
SIPVEFKLRELPKFHEHLHDTTWCMSGVGVGRERELLERYTHVTRAYSRL
GKAYQDVISGICERMANGMCDFLTRKVETKADYDLYCHYVAGLVGHGLTL
LYVSSGLEDVRLADDLTNANHMGLFLQKTNIIRDFYEDICEVPPRVFWPR
EIWEKYTDDLHAFKDELHEAKAVECLNAMVADALVHVPHVVEYLASLRDP
SVFAFSAIPQVMAMATLSLVFNNKDVFHTKVKTTRGATARIFHYSTELQA
TLQMLKTYTLRLAARMNAQDACYDRIEHLVNDAIRAMESHQ
3D structure
PDB3wsb The Tuberculosis Drug SQ109 Inhibits Trypanosoma cruzi Cell Proliferation and acts Synergistically with Posaconazole
ChainA
Resolution2.4 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y163 R210 R222 F282
Catalytic site (residue number reindexed from 1) Y136 R183 R195 F255
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FPS A S42 S44 F45 V171 G172 L175 M199 L203 Y270 S283 S15 S17 F18 V144 G145 L148 M172 L176 Y243 S256
BS02 RWZ A F45 F63 Y64 D71 V167 V171 Q204 F18 F36 Y37 D44 V140 V144 Q177
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3wsb, PDBe:3wsb, PDBj:3wsb
PDBsum3wsb
PubMed
UniProtQ4CWB4

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