Structure of PDB 3wqb Chain A

Receptor sequence

>3wqbA (length=597) Species: 646 (Aeromonas sobria)

NEGCAPLTGKESGMDIGRSSTERCLPGANPLQDQQWYLLNSGQDGFSARG
GIAGNDLNLWWAHRTGVLGQGVNVAVVDDGLAIAHPDLADNVRPGSKNVV
TGSDDPTPTDPDTAHGTSVSGIIAAVDNAIGTKGIAPRAQLQGFNLLDDN
SQQLQKDWLYALGDSNASRDNRVFNQSYGMSVVDPRSANSLDQSQLDRLF
EQQTLKAQGAAYIKAAGNGFNKIAAGGYVLNRTGNGPKLPFENSNLDPSN
SNFWNLVVSALNADGVRSSYSSVGSNIFLSATGGEYGTDTPAMVTTDLPG
CDMGYNRTDDPSTNRLHGNSQLDASCDYNGVMNGTASATPSTSGAMALLM
SAYPDLSVRDLRDLLARSATRVDAKHQPVMVSYTSSTGKVRDVKGLEGWE
RNAAGMWFSPTYGFGLIDVNKALELAANHQPLPPLVQLPWQKINVTGSAA
AIADVGNSPTSSTTRIATPLTVEAVQVMVSLDHQRLPDLLIELVSPAGTR
SILLSPFNSLVGQSLDQQQLGFVRTKGLRDMRMLSNKFYGESAQGTWRLE
VTDVANGTRQVSLLNRETRERTTLTERNNRQPGKLISWSLRVLGHDA

3D structure

• PDB: 3wqb Structural Basis for Action of the External Chaperone for a Propeptide-deficient Serine Protease from Aeromonas sobria.
• Chain: A
• Resolution: 1.41 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D78 H115 N218 A336
• Catalytic site (residue number reindexed from 1): D78 H115 N218 A336
• Enzyme Commision number: 3.4.21.121: Lys-Lys/Arg-Xaa endopeptidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CA	A	N29 D87 V126 N128 I130 T132	N29 D87 V126 N128 I130 T132
BS02	CA	A	D454 D488 D553 A555 N578 N579	D454 D488 D553 A555 N578 N579
BS03	CA	A	D297 L298 G300 M303 N306 C326	D297 L298 G300 M303 N306 C326

Gene Ontology

Molecular Function

• GO:0004252 serine-type endopeptidase activity
• GO:0008236 serine-type peptidase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006508 proteolysis

Cellular Component

• GO:0005576 extracellular region
• GO:0042597 periplasmic space

External links

• PDB: RCSB:3wqb, PDBe:3wqb, PDBj:3wqb
• PDBsum: 3wqb
• PubMed: 25784551
• UniProt: Q9L5A4|ASP_AERSO Aeromonas extracellular serine protease (Gene Name=asp)