Structure of PDB 3wpn Chain A

Receptor sequence
>3wpnA (length=309) Species: 9606 (Homo sapiens) [Search protein sequence]
KGKNIQVVVRCRPFNLAERKASAHSIVECDPVRKEVSVRTGGDKSSRKTY
TFDMVFGASTKQIDVYRSVVCPILDEVIMGYNCTIFAYGQTWEEDPLAGI
IPRTLHQIFEKLTDNGTEFSVKVSLLEIYNEELFDLLNPSSDVSERLQMF
DDPRNKRGVIIKGLEEITVHNKDEVYQILEKGAAKRTTASSRSHSVFSVT
IHMKETTIDGEELVKIGKLNLVDLAGSINQSLLTLGRVITALVERTPHVP
YRESKLTRILQDSLGGRTRTSIIATISPASLNLEETLSTLEYAHRAKNIL
NKPEVNQKL
3D structure
PDB3wpn Structural basis of new allosteric inhibition in Kinesin spindle protein eg5
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 B4S A Y104 L292 L293 Y352 A353 Y88 L232 L233 Y292 A293 PDBbind-CN: -logKd/Ki=4.36,IC50=44uM
BindingDB: IC50=120nM
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

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Molecular Function
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Biological Process
External links
PDB RCSB:3wpn, PDBe:3wpn, PDBj:3wpn
PDBsum3wpn
PubMed25622007
UniProtP52732|KIF11_HUMAN Kinesin-like protein KIF11 (Gene Name=KIF11)

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