Structure of PDB 3wpe Chain A

Receptor sequence
>3wpeA (length=714) Species: 9913 (Bos taurus) [Search protein sequence]
PAFLPCELQPHGQVDCNWLFLKSVPHFSAGAPRANVTSLSLISNRIHHLH
DSDFVHLSNLRVLNLKWNCPPAGLSPMHFPCRMTIEPNTFLAVPTLEELN
LSYNGITTVPALPSSLVSLSLSHTSILVLGPTHFTGLHALRFLYMDGNCY
YMNPCPRALEVAPGALLGLGNLTHLSLKYNNLTEVPRRLPPSLDTLLLSY
NHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCRECPKNFPKLHPDT
FSHLSRLEGLVLKDSSLYKLEKDWFRGLGRLQVLDLSENFLYDYITKTTI
FNDLTQLRRLNLSFNYHKKVSFAHLHLASSFGSLVSLEKLDMHGIFFRSL
TNITLQSLTRLPKLQSLHLQLNFINQAQLSIFGAFPSLLFVDLSDNRISS
CNLNFTLDLSRNNLVTIQQEMFTRLSRLQCLRLSHNSISQAVNGSQFVPL
TSLRVLDLSHNKLDLYHGRSFTELPQLEALDLSYNSQPFSMQGVGHNLSF
VAQLPSLRYLSLAHNGIHSRVSQKLSSASLRALDFSGNSLSQMWAEGDLY
LCFFKGLRNLVQLDLSENHLHTLLPRHLDNLPKSLRQLRLRDNNLAFFNW
SSLTVLPRLEALDLAGNQLKALSNGSLPPGIRLQKLDVSSNSIGFVIPGF
FVRATRLIELNLSANALKTVDPSWFGAGTLKILDVSANPLHCAAFVDFLL
ERQEAVPVTCGSPG
3D structure
PDB3wpe Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
ChainA
Resolution2.38 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A W46 K50 S71 R73 H76 W95 S103 P104 M105 F107 W18 K22 S43 R45 H48 W67 S75 P76 M77 F79
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3wpe, PDBe:3wpe, PDBj:3wpe
PDBsum3wpe
PubMed25686612
UniProtQ5I2M5|TLR9_BOVIN Toll-like receptor 9 (Gene Name=TLR9)

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