Structure of PDB 3wpc Chain A

Receptor sequence
>3wpcA (length=747) Species: 9796 (Equus caballus) [Search protein sequence]
TLPPFLPCELQPHGLVNCNWLFLKSVPHFSAAAPRDNVTSLSLLSNRIHH
LHDSDFAQLSNLQKLNLKWNCPPAGLSPMHFPCHMTIEPNTFLAVPTLEE
LNLSYNGITTVPALPSSLVSLILSRTNILQLDPTSLTGLHALRFLYMDGN
CYYKNPCGRALEVAPGALLGLGNLTHLSLKYNNLTTVPRSLPPSLEYLLL
SYNHIVTLAPEDLANLTALRVLDVGGNCRRCDHARNPCVECPHKFPQLHS
DTFSHLSRLEGLVLKDSSLYQLNPRWFRGLGNLTVLDLSENFLYDCITKT
KAFQGLAQLRRLNLSFNYHKKVSFAHLTLAPSFGSLLSLQELDMHGIFFR
SLSQKTLQPLARLPMLQRLYLQMNFINQAQLGIFKDFPGLRYIDLSDNRI
SGAVEEDFMPSCKNLSFTLDLSRNNLVTVQPEMFAQLSRLQCLRLSHNSI
SQAVNGSQFVPLTSLQVLDLSHNKLDLYHGRSFTELPRLEALDLSYNSQP
FSMRGVGHNLSFVAQLPTLRYLSLAHNGIHSRVSQQLCSTSLWALDFSGN
SLSQMWAEGDLYLRFFQGLRSLIRLDLSQNRLHTLLPCTLGNLPKSLQLL
RLRNNYLAFFNWSSLTLLPNLETLDLAGNQLKALSNGSLPSGTQLQRLDV
SRNSIIFVVPGFFALATRLRELNLSANALRTVEPSWFGFLAGSLEVLDVS
ANPLHCACAAFVDFLLQVQAAVPGLPSRVKCGSPGQLQGRSIFAQDL
3D structure
PDB3wpc Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
ChainA
Resolution1.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna A E616 H641 T642 E558 H583 T584 PDBbind-CN: Kd=20nM
BS02 dna A W47 F49 K51 S72 R74 H77 W96 S104 P105 M106 F108 Y132 R152 Y179 Y180 K181 Y208 Y229 R262 N263 W20 F22 K24 S45 R47 H50 W69 S77 P78 M79 F81 Y105 R125 Y152 Y153 K154 Y181 Y202 R235 N236 PDBbind-CN: Kd=20nM
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Cellular Component
External links
PDB RCSB:3wpc, PDBe:3wpc, PDBj:3wpc
PDBsum3wpc
PubMed25686612
UniProtQ2EEY0|TLR9_HORSE Toll-like receptor 9 (Gene Name=TLR9)

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