Structure of PDB 3woq Chain A

Receptor sequence

>3woqA (length=697) Species: 128785 (Pseudoxanthomonas mexicana)

GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASF
VSPNGLVVTNHACAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARV
FVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRC
RLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGA
FAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPG
STNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAAT
MAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALD
AHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAE
RESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVA
AVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPA
IQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPD
ANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLD
AVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNAGSPVLDAHGKLVGLAFD
GNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNVG

3D structure

• PDB: 3woq S46 peptidases are the first exopeptidases to be members of clan PA
• Chain: A
• Resolution: 1.82 Å

Enzymatic activity

• Enzyme Commision number: 3.4.14.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	A	G69 N215 W216 Y300 G327 W328 N330 T331 I652 T653 G654 G655 A657 F673 D674 G675	G45 N191 W192 Y276 G303 W304 N306 T307 I628 T629 G630 G631 A633 F649 D650 G651
BS02	ZN	A	E505 K508	E481 K484

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004177 aminopeptidase activity
• GO:0008239 dipeptidyl-peptidase activity
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity
• GO:0070009 serine-type aminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0009056 catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

External links

• PDB: RCSB:3woq, PDBe:3woq, PDBj:3woq
• PDBsum: 3woq
• PubMed: 24827749
• UniProt: V5YM14|DAPB2_PSEMX Dipeptidyl aminopeptidase BII (Gene Name=dapb2)