Structure of PDB 3wol Chain A

Receptor sequence

>3wolA (length=696) Species: 128785 (Pseudoxanthomonas mexicana)

GEGMWVPQQLPEIAGPLKKAGLKLSPQQISDLTGDPMGAVVALGGCTASF
VSPNGLVVTNHHCAYGAIQLNSTAENNLIKNGFNAPTTADEVSAGPNARV
FVLDEITDVTKDAKAAIAAAGDDALARTKALEAFEKKLIADCEAEAGFRC
RLYSFSGGNTYRLFKNLEIKDVRLAYAPPGSVGKFGGDIDNWMWPRHTGD
FAFYRAYVGKDGKPAAFSKDNVPYQPKHWLKFADQPLGAGDFVMVAGYPG
STNRYALAAEFDNTAQWTYPTIARHYKNQIAMVEAAGKQNADIQVKYAAT
MAGWNNTSKNYDGQLEGFKRIDAAGQKLREEAAVLGWLKGQGAKGQPALD
AHAKLLDLLEQSKATRDRDLTLALFNNTAMLGSATQLYRLSIEREKPNAE
RESGYQERDLPAIEGGLKQLERRYVAAMDRQLQEYWLNEYIKLPADQRVA
AVDAWLGGNDAAAVKRALDRLAGTKLGSTEERLKWFAADRKAFEASNDPA
IQYAVAVMPTLLKLEQERKTRAGENLAARPVYLQALADYKKSQGEFVYPD
ANLSLRITFGNVMGYAPKDGMEYTPFTTLEGVVAKETGQDPFDSPKALLD
AVAAKRYGGLEDKRIGSVPVNYLSDLDITGGNSGSPVLDAHGKLVGLAFD
GNWESVSSNWVFDPKMTRMIAVDGRYLRWIMQEVYPAPQLLKEMNV

3D structure

• PDB: 3wol S46 peptidases are the first exopeptidases to be members of clan PA
• Chain: A
• Resolution: 1.74 Å

Enzymatic activity

• Enzyme Commision number: 3.4.14.-

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	VAL	A	H86 N215 W216 N330 F673 D674	H62 N191 W192 N306 F649 D650
BS02	TYR	A	H86 W216 I652 T653 G654 S657 D674 G675	H62 W192 I628 T629 G630 S633 D650 G651

Gene Ontology

Molecular Function

• GO:0004175 endopeptidase activity
• GO:0004177 aminopeptidase activity
• GO:0008239 dipeptidyl-peptidase activity
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity
• GO:0070009 serine-type aminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0009056 catabolic process
• GO:0051603 proteolysis involved in protein catabolic process

External links

• PDB: RCSB:3wol, PDBe:3wol, PDBj:3wol
• PDBsum: 3wol
• PubMed: 24827749
• UniProt: V5YM14|DAPB2_PSEMX Dipeptidyl aminopeptidase BII (Gene Name=dapb2)