Structure of PDB 3wj5 Chain A

Receptor sequence
>3wj5A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
GSESADLRALAKHLYDSYIKSFPLTKAKARAILTGKKSPFVIYDMNSLMM
GEDKISKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLL
KYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKF
EFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALE
LQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPL
LQEIYKDL
3D structure
PDB3wj5 Structural basis for PPARgamma transactivation by endocrine disrupting organotin compounds
ChainA
Resolution1.89 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 T9T A F282 C285 Q286 Y327 F363 M364 H449 L453 Y473 F64 C67 Q68 Y109 F145 M146 H231 L235 Y255
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Cellular Component
External links
PDB RCSB:3wj5, PDBe:3wj5, PDBj:3wj5
PDBsum3wj5
PubMed
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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