Structure of PDB 3wiz Chain A

Receptor sequence
>3wizA (length=141) Species: 9606 (Homo sapiens) [Search protein sequence]
QSNRELVVDFLSYKLSQKGYSWSQFTESEAVKQALREAGDEFELRYRRAF
SDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESV
DKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYG
3D structure
PDB3wiz Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
ChainA
Resolution2.45 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LC6 A E96 F97 Y101 L108 E129 L130 W137 G138 R139 V141 E41 F42 Y46 L53 E74 L75 W82 G83 R84 V86 MOAD: ic50=0.0044uM
PDBbind-CN: -logKd/Ki=8.36,IC50=4.4nM
BindingDB: IC50=4.4nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3wiz, PDBe:3wiz, PDBj:3wiz
PDBsum3wiz
PubMed24215352
UniProtQ07817|B2CL1_HUMAN Bcl-2-like protein 1 (Gene Name=BCL2L1)

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