Structure of PDB 3wix Chain A

Receptor sequence
>3wixA (length=150) Species: 9606 (Homo sapiens) [Search protein sequence]
DELYRQSLEIISRYLREQATGAKDTKPMGRSGATSRKALETLRRVGDGVQ
RNHETAFQGMLRKLDIKNEDDVKSLSRVMIHVFSDGVTNWGRIVTLISFG
AFVAKHLKTINQESCIEPLAESITDVLVRTKRDWLVKQRGWDGFVEFFHV
3D structure
PDB3wix Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins.
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LC3 A A227 F228 M250 V253 F254 R263 T266 L267 F270 I294 A56 F57 M79 V82 F83 R92 T95 L96 F99 I123 MOAD: ic50=0.54uM
PDBbind-CN: -logKd/Ki=6.27,IC50=0.54uM
BindingDB: IC50=540nM
BS02 LC3 A P198 M199 R201 S202 R207 P27 M28 R30 S31 R36 MOAD: ic50=0.54uM
PDBbind-CN: -logKd/Ki=6.27,IC50=0.54uM
BindingDB: IC50=540nM
Gene Ontology
Biological Process
GO:0042981 regulation of apoptotic process

View graph for
Biological Process
External links
PDB RCSB:3wix, PDBe:3wix, PDBj:3wix
PDBsum3wix
PubMed24215352
UniProtQ07820|MCL1_HUMAN Induced myeloid leukemia cell differentiation protein Mcl-1 (Gene Name=MCL1)

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