Structure of PDB 3wff Chain A

Receptor sequence
>3wffA (length=258) Species: 9606 (Homo sapiens) [Search protein sequence]
LSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQ
MIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQF
LYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLL
LLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKCPNNSGQSWQRFYQLTK
LLDSMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNV
KPLYFHRK
3D structure
PDB3wff Design, synthesis, and structure-activity relationships of dihydrofuran-2-one and dihydropyrrol-2-one derivatives as novel benzoxazin-3-one-based mineralocorticoid receptor antagonists.
ChainA
Resolution2.05 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 WFF A N770 A773 M807 S811 L814 F829 M845 M852 L938 F941 C942 T945 N44 A47 M81 S85 L88 F103 M119 M126 L212 F215 C216 T219 PDBbind-CN: -logKd/Ki=6.18,IC50=660nM
BindingDB: IC50=660nM
External links
PDB RCSB:3wff, PDBe:3wff, PDBj:3wff
PDBsum3wff
PubMed23958516
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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