Structure of PDB 3wf5 Chain A

Receptor sequence
>3wf5A (length=278) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKTKAERNI
LEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTAC
FYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHD
GTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGE
NRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEV
QAHPFFRHINWEELLARKVEPPFKPLLQ
3D structure
PDB3wf5 Crystal structures of the S6K1 kinase domain in complexes with inhibitors
ChainA
Resolution2.099 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D122 K124 E126 N127 D140 T160
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C240 H245 H251 C254 C144 H149 H155 C158
BS02 FZ8 A K99 G100 V105 A121 E173 L175 K241 K15 G16 V21 A37 E77 L79 K145 MOAD: ic50=81nM
PDBbind-CN: -logKd/Ki=7.09,IC50=81nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3wf5, PDBe:3wf5, PDBj:3wf5
PDBsum3wf5
PubMed25078151
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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