Structure of PDB 3wei Chain A

Receptor sequence
>3weiA (length=334) Species: 9606 (Homo sapiens) [Search protein sequence]
LSSSLKTCYKYLNQTSRSFAAVIQALDGEMRNAVCIFALVLRALDTLEDD
MTISVEKKVPLLHNFHSFLYQPDWRFMESKEKDRQVLEDFPTISLEFRNL
AEKYQTVIADICRRMGIGMAEFLDKHVTSEQEWDKYCHYVAGLVGIGLSR
LFSASEFEDPLVGEDTERANSMGLFLQKTNIIRDYLEDQQGGREFWPQEV
WSRYVKKLGDFAKPENIDLAVQCLNELITNALHHIPDVITYLSRLRNQSV
FNFCAIPQVMAIATLAACYNNQQVFKGAVKIRKGQAVTLMMDATNMPAVK
AIIYQYMEEIYHRIPDSDPSSSKTRQIISTIRTQ
3D structure
PDB3wei Structural insights into the catalytic mechanism of human squalene synthase.
ChainA
Resolution1.79 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y171 R218 R228 F288
Catalytic site (residue number reindexed from 1) Y136 R183 R193 F253
Enzyme Commision number 2.5.1.21: squalene synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MN A N215 D219 N180 D184
BS02 MN A D80 E83 D84 D45 E48 D49
BS03 MN A D80 D84 D45 D49
BS04 PS7 A F54 A73 L76 R77 D80 D84 V175 V179 G180 M207 L211 Q212 Y276 F288 F19 A38 L41 R42 D45 D49 V140 V144 G145 M172 L176 Q177 Y241 F253
Gene Ontology
Molecular Function
GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups
GO:0051996 squalene synthase [NAD(P)H] activity
Biological Process
GO:0008610 lipid biosynthetic process
GO:0009058 biosynthetic process
GO:0045338 farnesyl diphosphate metabolic process

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Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3wei, PDBe:3wei, PDBj:3wei
PDBsum3wei
PubMed24531458
UniProtP37268|FDFT_HUMAN Squalene synthase (Gene Name=FDFT1)

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