Structure of PDB 3we4 Chain A

Receptor sequence
>3we4A (length=287) Species: 9606 (Homo sapiens) [Search protein sequence]
KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNA
KDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQL
EREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKL
TDFGLCKESIHDTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDML
TGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLG
AGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQ
3D structure
PDB3we4 Crystal structures of the S6K1 kinase domain in complexes with inhibitors
ChainA
Resolution1.995 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D218 K220 E222 N223 D236 T256
Catalytic site (residue number reindexed from 1) D134 K136 E138 N139 D152 T169
Enzyme Commision number 2.7.11.1: non-specific serine/threonine protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A C240 H245 H251 C254 C156 H161 H164 C167
BS02 5FI A K99 G100 G103 V105 A121 K123 L125 E173 Y174 L175 M225 K241 K15 G16 G19 V21 A37 K39 L41 E89 Y90 L91 M141 K157 MOAD: ic50=15nM
PDBbind-CN: -logKd/Ki=7.82,IC50=15nM
BindingDB: Ki=20nM,IC50=160nM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004674 protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3we4, PDBe:3we4, PDBj:3we4
PDBsum3we4
PubMed25078151
UniProtP23443|KS6B1_HUMAN Ribosomal protein S6 kinase beta-1 (Gene Name=RPS6KB1)

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