Structure of PDB 3wcz Chain A

Receptor sequence
>3wczA (length=307) Species: 7091 (Bombyx mori) [Search protein sequence]
AVQAPCIQLNDGNTIPIVALGTGRGTAKESDSIDEVRQAVYWAIEAGYRH
IDTAAVYQDEEQVGQGIAEAIANGLVTREELFVTTKLWNDKHARDQVVPA
LQESLKKLGLDYIDLYLIHFPIATKPDDSPDNIDYLETWQGMQDARQLGL
ARSIGVSNFNATQITRLVSNSYIRPVINQIEVNPTNTQEPLVAHCQSLGI
AVMAYSPFGFVVSRGQTGAPPPRSDDPTLTALANKYRKSVGQILLRYLID
RGLIPIPKSTNKQRIAQNIDLFDFQLTFEEVAAINQFNKNHRVIDISDWK
DYPNYPN
3D structure
PDB3wcz Identification, characterization, and crystal structure of an aldo-keto reductase (AKR2E4) from the silkworm Bombyx mori.
ChainA
Resolution1.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D53 Y58 K87 H120
Catalytic site (residue number reindexed from 1) D52 Y57 K86 H119
Enzyme Commision number 1.1.1.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP A G22 T23 G24 T27 D53 Y58 H120 Q180 Y206 S207 P208 F209 R215 I257 P258 K259 S260 T261 R265 N269 G21 T22 G23 T26 D52 Y57 H119 Q179 Y205 S206 P207 F208 R214 I256 P257 K258 S259 T260 R264 N268
Gene Ontology
Molecular Function
GO:0004032 aldose reductase (NADPH) activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0008202 steroid metabolic process
Cellular Component
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:3wcz, PDBe:3wcz, PDBj:3wcz
PDBsum3wcz
PubMed24012638
UniProtH9JTG9|AK2E4_BOMMO Aldo-keto reductase AKR2E4 (Gene Name=akr2e)

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