Structure of PDB 3wc7 Chain A

Receptor sequence
>3wc7A (length=304) Species: 9823 (Sus scrofa) [Search protein sequence]
GHSYEKYNNWETIEAWTKQVTSENPDLISRTAIGTTFLGNNIYLLKVGKP
GPNKPAIFMDCGFHAREWISHAFCQWFVREAVLTYGYESHMTEFLNKLDF
YVLPVLNIDGYIYTWTKNRMWRKTRSTNAGTTCIGTDPNRNFDAGWCTTG
ASTDPCDETYCGSAAESEKETKALADFIRNNLSSIKAYLTIHSYSQMILY
PYSYDYKLPENNAELNNLAKAAVKELATLYGTKYTYGPGATTIYPAAGGS
DDWAYDQGIKYSFTFELRDKGRYGFILPESQIQATCEETMLAIKYVTNYV
LGHL
3D structure
PDB3wc7 Structural basis for inhibition of carboxypeptidase B by selenium-containing inhibitor: selenium coordinates to zinc in enzyme.
ChainA
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) H69 E72 R127 H196 E270
Catalytic site (residue number reindexed from 1) H64 E67 R122 H192 E266
Enzyme Commision number 3.4.17.2: carboxypeptidase B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A E85 E291 E80 E287
BS02 ZN A H69 E72 H196 H64 E67 H192
BS03 EF1 A H69 E72 R127 N144 R145 H196 S197 Y198 S207 I247 Y248 D255 E270 F279 H64 E67 R122 N139 R140 H192 S193 Y194 S203 I243 Y244 D251 E266 F275 PDBbind-CN: -logKd/Ki=8.26,IC50=5.5nM
BindingDB: IC50=4.9nM
Gene Ontology
Molecular Function
GO:0004181 metallocarboxypeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3wc7, PDBe:3wc7, PDBj:3wc7
PDBsum3wc7
PubMed24010887
UniProtP09955|CBPB1_PIG Carboxypeptidase B (Gene Name=CPB1)

[Back to BioLiP]