Structure of PDB 3w8r Chain A

Receptor sequence
>3w8rA (length=207) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence]
KPFVIGIAGGTASGKTTLAQALARTLGERVALLPMDHYYKDLGHLPLEER
LRVNYDHPDAFDLALYLEHAQALLRGLPVEMPVYDFRAHTRSPRRTPVRP
APVVILEGILVLYPKELRDLMDLKVFVDADADERFIRRLKRDVLERGRSL
EGVVAQYLEQVKPMHLHFVEPTKRYADVIVPRGGQNPVALEMLAAKALAR
LARMGAA
3D structure
PDB3w8r Indispensable residue for uridine binding in the uridine-cytidine kinase family.
ChainA
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.48: uridine/cytidine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CTN A D40 Y43 Y59 D60 Y88 R142 R152 Q160 D36 Y39 Y55 D56 Y84 R138 R148 Q156
BS02 ACP A T15 A16 S17 G18 K19 T20 T21 R145 T11 A12 S13 G14 K15 T16 T17 R141
Gene Ontology
Molecular Function
GO:0004849 uridine kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0016887 ATP hydrolysis activity
GO:0043771 cytidine kinase activity
Biological Process
GO:0008655 pyrimidine-containing compound salvage
GO:0009224 CMP biosynthetic process
GO:0016310 phosphorylation
GO:0044206 UMP salvage
GO:0044211 CTP salvage
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w8r, PDBe:3w8r, PDBj:3w8r
PDBsum3w8r
PubMed28955773
UniProtQ5SKR5|URK_THET8 Uridine kinase (Gene Name=udk)

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