Structure of PDB 3w8k Chain A

Receptor sequence
>3w8kA (length=347) Species: 573 (Klebsiella pneumoniae) [Search protein sequence]
DPLRPVVDASIQPLLKEHRIPGMAVAVLKDGKAHYFNYGVANRESGASVS
EQTLFEIGSVSKTLTATLGAYAVVKGAMQLDDKASRHAPWLKGSVFDSIT
MGELATYSAGGLPLQFPEEVDSSEKMRAYYRQWAPVYSPGSHRQYSNPSI
GLFGHLAASSLKQPFAQLMEQTLLPGLGMHHTYVNVPKQAMASYAYGYSK
EDKPIRVGMLADEAYGIKTSSADLLAFVKANIGGVDDKALQQAISLTHKG
HYSVGGMTQGLGWESYAYPVTEQTLLAGNSAKVILEANPTAAPRQVLFNK
TGSSNGFGAYVAFVPARGIGIVMLANRNYPIPARVKAAHAILAQLAG
3D structure
PDB3w8k Crystal structure of Mox-1, a unique plasmid-mediated class C beta-lactamase with hydrolytic activity towards moxalactam
ChainA
Resolution1.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S65 K68 M107 E109 F122 Y151 G157 E272 K312 S315
Catalytic site (residue number reindexed from 1) S59 K62 M101 E103 F116 Y145 G151 E264 K300 S303
Enzyme Commision number 3.5.2.6: beta-lactamase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A V278 H351 V270 H339
BS02 ZN A H187 D231 H181 D223
BS03 ZN A D7 H40 D1 H34
Gene Ontology
Molecular Function
GO:0008800 beta-lactamase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0017001 antibiotic catabolic process
GO:0046677 response to antibiotic
Cellular Component
GO:0030288 outer membrane-bounded periplasmic space

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Cellular Component
External links
PDB RCSB:3w8k, PDBe:3w8k, PDBj:3w8k
PDBsum3w8k
PubMed24777102
UniProtQ51578

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