Structure of PDB 3w5o Chain A

Receptor sequence
>3w5oA (length=577) Species: 9606 (Homo sapiens) [Search protein sequence]
QTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHKNH
VTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKDALKL
LNYRTGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKRKDLI
KKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAELHNV
TTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDMKHQS
FYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTPFIHN
AFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTCYCVF
DVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNEVIDA
LNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEELDILIVGGYWGKG
SGMMSHFLCAVAEKPPPGEKPSVFHTLSRVGSGCTMKELYDLGLKLAKYW
KPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYKTGCTL
RFPRIEKIRDDKEWHECMTLDDLEQLR
3D structure
PDB3w5o Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair
ChainA
Resolution2.84 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ATP A K273 L274 D275 E331 F367 M430 K432 K449 K451 K256 L257 D258 E314 F350 M413 K415 K432 K434
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3w5o, PDBe:3w5o, PDBj:3w5o
PDBsum3w5o
PubMed23523427
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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