Structure of PDB 3w5h Chain A

Receptor sequence
>3w5hA (length=272) Species: 9823 (Sus scrofa) [Search protein sequence]
STPAITLENPDIKYPLRLIDKEVVNHDTRRFRFALPSPEHILGLPVGQHI
YLSARIDGNLVIRPYTPVSSDDDKGFVDLVIKVYFKDTHPKFPAGGKMSQ
YLESMKIGDTIEFRGPNGLLVYQGKGKFAIRPDKKSSPVIKTVKSVGMIA
GGTGITPMLQVIRAIMKDPDDHTVCHLLFANQTEKDILLRPELEELRNEH
SARFKLWYTVDRAPEAWDYSQGFVNEEMIRDHLPPPEEEPLVLMCGPPPM
IQYACLPNLERVGHPKERCFAF
3D structure
PDB3w5h Elucidations of the catalytic cycle of NADH-cytochrome b5 reductase by X-ray crystallography: new insights into regulation of efficient electron transfer
ChainA
Resolution0.78 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) H1049 Y1065 T1066 C1245
Catalytic site (residue number reindexed from 1) H49 Y65 T66 C245
Enzyme Commision number 1.6.2.2: cytochrome-b5 reductase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A R1063 P1064 Y1065 T1066 V1080 Y1084 H1089 F1092 G1095 G1096 K1097 M1098 S1099 T1153 T1156 P1157 R63 P64 Y65 T66 V80 Y84 H89 F92 G95 G96 K97 M98 S99 T153 T156 P157
Gene Ontology
Molecular Function
GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H
GO:0016491 oxidoreductase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006695 cholesterol biosynthetic process
Cellular Component
GO:0005575 cellular_component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3w5h, PDBe:3w5h, PDBj:3w5h
PDBsum3w5h
PubMed23831226
UniProtP83686|NB5R3_PIG NADH-cytochrome b5 reductase 3 (Fragment) (Gene Name=CYB5R3)

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