Structure of PDB 3w1g Chain A

Receptor sequence
>3w1gA (length=583) Species: 9606 (Homo sapiens) [Search protein sequence]
TSQTVASHVPFADLCSTLERIQKSKGRAEKIRHFREFLDSWRKFHDALHK
NHKDVTDSFYPAMRLILPQLERERMAYGIKETMLAKLYIELLNLPRDGKD
ALKLLNYRTGDFAMIAYFVLKPRCLQKGSLTIQQVNDLLDSIASNNSAKR
KDLIKKSLLQLITQSSALEQKWLIRMIIKDLKLGVSQQTIFSVFHNDAAE
LHNVTTDLEKVCRQLHDPSVGLSDISITLFSAFKPMLAAIADIEHIEKDM
KHQSFYIETKLDGERMQMHKDGDVYKYFSRNGYNYTDQFGASPTEGSLTP
FIHNAFKADIQICILDGEMMAYNPNTQTFMQKGTKFDIKRMVEDSDLQTC
YCVFDVLMVNNKKLGHETLRKRYEILSSIFTPIPGRIEIVQKTQAHTKNE
VIDALNEAIDKREEGIMVKQPLSIYKPDKRGEGWLKIKPEYVSMDELDIL
IVGGYWGKGSGMMSHFLCAVAEKPPPSVFHTLSRVGSGCTMKELYDLGLK
LAKYWKPFHRKAPPSSILCGTEKPEVYIEPCNSVIVQIKAAEIVPSDMYK
TGCTLRFPRIEKIRDDKEWHECMTLDDLEQLRG
3D structure
PDB3w1g Structure of the catalytic region of DNA ligase IV in complex with an artemis fragment sheds light on double-strand break repair
ChainA
Resolution2.55 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 6.5.1.1: DNA ligase (ATP).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A V14 D18 R25 S45 K48 F49 A52 V9 D13 R20 S40 K43 F44 A47
BS02 ATP A T272 K273 L274 D275 E331 F367 E427 M430 K432 W447 K449 K451 T259 K260 L261 D262 E318 F354 E414 M417 K419 W434 K436 K438
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003909 DNA ligase activity
GO:0003910 DNA ligase (ATP) activity
GO:0005524 ATP binding
Biological Process
GO:0006281 DNA repair
GO:0006310 DNA recombination
GO:0051103 DNA ligation involved in DNA repair
GO:0071897 DNA biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3w1g, PDBe:3w1g, PDBj:3w1g
PDBsum3w1g
PubMed23523427
UniProtP49917|DNLI4_HUMAN DNA ligase 4 (Gene Name=LIG4)

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