Structure of PDB 3w0h Chain A

Receptor sequence
>3w0hA (length=247) Species: 10116 (Rattus norvegicus) [Search protein sequence]
SHDSLRPKLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSML
PHLADLVSYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQ
SFTMDDMSWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHE
EEHVLLMAICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSH
QLYAKMIQKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB3w0h Structural basis for vitamin D receptor agonism by novel non-secosteroidal ligands.
ChainA
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 R248 S252 I256 K260 P412 E416 I65 K69 R75 S79 I83 K87 P239 E243
BS02 W12 A Y143 L226 A227 L229 I267 M268 S271 S274 W282 H301 H393 Y28 L53 A54 L56 I94 M95 S98 S101 W109 H128 H220
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3w0h, PDBe:3w0h, PDBj:3w0h
PDBsum3w0h
PubMed23462137
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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