Structure of PDB 3vzv Chain A

Receptor sequence
>3vzvA (length=85) Species: 9606 (Homo sapiens) [Search protein sequence]
ETLVRPKPELLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHI
VYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
3D structure
PDB3vzv Lead optimization of novel p53-MDM2 interaction inhibitors possessing dihydroimidazothiazole scaffold
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VZV A L54 G58 M62 Y67 Q72 V93 H96 Y100 L30 G34 M38 Y43 Q48 V69 H72 Y76 PDBbind-CN: -logKd/Ki=8.04,IC50=9.2nM
Gene Ontology
Biological Process
GO:0043066 negative regulation of apoptotic process
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:3vzv, PDBe:3vzv, PDBj:3vzv
PDBsum3vzv
PubMed23266121
UniProtQ00987|MDM2_HUMAN E3 ubiquitin-protein ligase Mdm2 (Gene Name=MDM2)

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