Structure of PDB 3vws Chain A

Receptor sequence
>3vwsA (length=592) Species: 11069 (dengue virus type 3) [Search protein sequence]
NMDVIGERIKRIKEEHNSTWHYDDENPYKTWAYHGSYEVKATSMINGVVK
LLTKPWDVVPMVTQMAMTQRVFKEKVDTRTPRPLPGTRKVMEITAEWLWR
TLGRNKRPRLCTREEFTKKVRTNAAMGAVFTEENQWDSAKAAVEDEEFWK
LVDRERELHKLGKCGSCVYNMMGGKAKGSRAIWYMWLGVRYLEFEALGFL
NEDHWFSRENSYSGVEGEGLHKLGYILRDISKIPGGAMYADDTAGWDTRI
TEDDLHNEEKIIQQMDPEHRQLANAIFKLTYQNKVVKVQRPTPTGTVMDI
ISRKDQRGSGQVGTYGLNTFTNMEAQLVRQMEGEGVLTKADLENPHLLEK
KITQWLETKGVERLKRMAISGDDCVVKPIDDRFANALLALNDMGKVRKDI
PQWQPSKGWHDWQQVPFCSHHFHELIMKDGRKLVVPCRPQDELIGRARIS
QGAGWSLRETACLGKAYAQMWSLMYFHRRDLRLASNAICSAVPVHWVPTS
RTTWSIHAHHQWMTTEDMLTVWNRVWIEENPWMEDKTPVTTWENVPYLGK
REDQWCGSLIGLTSRATWAQNIPTAIQQVRSLIGNEEFLDYM
3D structure
PDB3vws Conformational flexibility of the Dengue virus RNA-dependent RNA polymerase revealed by a complex with an inhibitor
ChainA
Resolution2.1 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.56: mRNA (guanine-N(7))-methyltransferase.
2.1.1.57: methyltransferase cap1.
2.7.7.48: RNA-directed RNA polymerase.
3.4.21.91: flavivirin.
3.6.1.15: nucleoside-triphosphate phosphatase.
3.6.4.13: RNA helicase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H712 H714 C728 C847 H421 H423 C437 C556
BS02 ZN A E437 H441 C446 C449 E155 H159 C164 C167
BS03 VWS A N405 V411 F412 T413 F485 W795 N123 V129 F130 T131 F194 W504 MOAD: Kd=225uM
PDBbind-CN: -logKd/Ki=3.65,Kd=225uM
BS04 VWS A F412 N492 Q602 V603 G604 T605 Y606 I797 F130 N201 Q311 V312 G313 T314 Y315 I506 MOAD: Kd=225uM
PDBbind-CN: -logKd/Ki=3.65,Kd=225uM
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005524 ATP binding
Biological Process
GO:0039694 viral RNA genome replication

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Molecular Function
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Biological Process
External links
PDB RCSB:3vws, PDBe:3vws, PDBj:3vws
PDBsum3vws
PubMed23408636
UniProtQ6YMS4|POLG_DEN3S Genome polyprotein (Gene Name=pol)

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