Structure of PDB 3vuz Chain A

Receptor sequence
>3vuzA (length=246) Species: 9606 (Homo sapiens) [Search protein sequence]
GSSGSSGHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGK
FIDGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLP
DPYESERVYVAESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSR
DWALNGNTLSLDEETVIDVPEPYNHVSKYCASLGHKANHSFTPNCIYDMF
VHPRFGPIKCIRTLRAVEADEELTVAYGYDHEAPEWYQVELKAFQA
3D structure
PDB3vuz Structures of histone methyltransferase SET7/9 in complexes with adenosylmethionine derivatives
ChainA
Resolution2.5 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y245 H293 H297 Y305 Y335
Catalytic site (residue number reindexed from 1) Y137 H185 H189 Y197 Y227
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 K15 A A226 E228 Y245 G264 N282 H293 K294 N296 H297 Y335 W352 A118 E120 Y137 G156 N174 H185 K186 N188 H189 Y227 W236
Gene Ontology
Molecular Function
GO:0016279 protein-lysine N-methyltransferase activity
GO:0140945 histone H3K4 monomethyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Cellular Component
External links
PDB RCSB:3vuz, PDBe:3vuz, PDBj:3vuz
PDBsum3vuz
PubMed23519668
UniProtQ8WTS6|SETD7_HUMAN Histone-lysine N-methyltransferase SETD7 (Gene Name=SETD7)

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