Structure of PDB 3vtc Chain A

Receptor sequence
>3vtcA (length=240) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLADLV
SYSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDM
SWDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLM
AICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMI
QKLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFGN
3D structure
PDB3vtc Combination of Triple Bond and Adamantane Ring on the Vitamin D Side Chain Produced Partial Agonists for Vitamin D Receptor.
ChainA
Resolution1.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 S252 I256 K260 P412 E416 N420 I58 K62 S72 I76 K80 P232 E236 N240
BS02 TK3 A Y143 V230 S233 R270 S271 S274 W282 C284 H301 L309 H393 L400 Y21 V50 S53 R90 S91 S94 W102 C104 H121 L129 H213 L220 MOAD: ic50=13nM
PDBbind-CN: -logKd/Ki=7.89,IC50=13nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3vtc, PDBe:3vtc, PDBj:3vtc
PDBsum3vtc
PubMed24773565
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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