Structure of PDB 3vsd Chain A

Receptor sequence
>3vsdA (length=382) Species: 272557 (Aeropyrum pernix K1) [Search protein sequence]
ALADISGYLDVLDSVRGFSYLENAREVLRSGEARCLGNPRSEPEYVKALY
VIGASRIPVGDGCSHTLEELGVFDISVPGEMVFPSPLDFFERGKPTPLVR
SRLQLPNGVRVWLKLEWYNPFSLSVADRPAVEIISRLSRRVEKGSLVADA
TSSNFGVALSAVARLYGYRARVYLPGAAEEFGKLLPRLLGAQVIVDPEAP
STVHLLPRVMKDSKNEGFVHVNQFYNDANFEAHMRGTAREIFVQSRRGGL
ALRGVAGSLGTSGHMSAAAFYLQSVDPSIRAVLVQPAQGDSIPGIRRVET
GMLWINMLDISYTLAEVTLEEAMEAVVEVARSDGLVIGPSGGAAVKALAK
KAAEGDLEPGDYVVVVPDTGFKYLSLVQNALE
3D structure
PDB3vsd Structural analysis of the substrate recognition mechanism in O-phosphoserine sulfhydrylase from the hyperthermophilic archaeon Aeropyrum pernix K1
ChainA
Resolution2.09 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) A127 S341
Catalytic site (residue number reindexed from 1) A126 S340
Enzyme Commision number 2.5.1.47: cysteine synthase.
2.5.1.65: O-phosphoserine sulfhydrylase.
4.2.1.22: cystathionine beta-synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP A N155 L260 G261 T262 S263 G264 H265 G295 S341 P368 D369 N154 L259 G260 T261 S262 G263 H264 G294 S340 P367 D368
BS02 OAS A T152 S153 N155 F156 T203 Q224 G261 T151 S152 N154 F155 T202 Q223 G260
Gene Ontology
Molecular Function
GO:0004122 cystathionine beta-synthase activity
GO:0004124 cysteine synthase activity
GO:0016740 transferase activity
GO:0016829 lyase activity
GO:0033847 O-phosphoserine sulfhydrylase activity
Biological Process
GO:0006534 cysteine metabolic process
GO:0006535 cysteine biosynthetic process from serine
GO:0009069 serine family amino acid metabolic process
GO:0019344 cysteine biosynthetic process
GO:0044272 sulfur compound biosynthetic process
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3vsd, PDBe:3vsd, PDBj:3vsd
PDBsum3vsd
PubMed22580223
UniProtQ9YBL2|CYSO_AERPE Protein CysO (Gene Name=cysO)

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