Structure of PDB 3vs4 Chain A

Receptor sequence
>3vs4A (length=430) Species: 9606 (Homo sapiens) [Search protein sequence]
RIIVVALYDYEAIHHEDLSFQKGDQMVVLEESGEWWKARSLATRKEGYIP
SNYVARVDSLETEEWFFKGISRKDAERQLLAPGNMLGSFMIRDSETTKGS
YSLSVRDYDPRQGDTVKHYKIRFYISPRSTFSTLQELVDHYKKGNDGLCQ
KLSVPCMSSKPQKPWEKDAWEIPRESLKLEKKLGAGQFGEVWMATYNKHT
KVAVKTMKPGSMSVEAFLAEANVMKTLQHDKLVKLHAVVTKEPIYIITEF
MAKGSLLDFLKSDEGSKQPLPKLIDFSAQIAEGMAFIEQRNYIHRDLRAA
NILVSASLVCKIADFGLARVIEFPIKWTAPEAINFGSFTIKSDVWSFGIL
LMEIVTYGRIPYPGMSNPEVIRALERGYRMPRPENCPEELYNIMMRCWKN
RPEERPTFEYIQSVLDDFYTATESQYEEIP
3D structure
PDB3vs4 A Pyrrolo-Pyrimidine Derivative Targets Human Primary AML Stem Cells in Vivo
ChainA
Resolution2.747 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D386 R388 A390 N391 D404 F424
Catalytic site (residue number reindexed from 1) D296 R298 A300 N301 D314 F323
Enzyme Commision number 2.7.10.2: non-specific protein-tyrosine kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VSF A V281 A293 K295 V323 T338 M341 L393 D404 F405 V191 A203 K205 V233 T248 M251 L303 D314 F315 BindingDB: IC50=31nM
BS02 CA A E524 Y527 E529 E423 Y426 E428
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3vs4, PDBe:3vs4, PDBj:3vs4
PDBsum3vs4
PubMed23596204
UniProtP08631|HCK_HUMAN Tyrosine-protein kinase HCK (Gene Name=HCK)

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