Structure of PDB 3vrw Chain A

Receptor sequence
>3vrwA (length=238) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMPLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMS
WDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMA
ICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQ
KLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFG
3D structure
PDB3vrw Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands
ChainA
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 S252 K260 P412 E416 I57 K61 S71 K79 P231 E235
BS02 YS5 A Y143 S233 R270 S271 S274 W282 C284 V296 H301 L305 H393 Y21 S52 R89 S90 S93 W101 C103 V115 H120 L124 H212 MOAD: ic50=0.41nM
PDBbind-CN: -logKd/Ki=9.39,IC50=0.41nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3vrw, PDBe:3vrw, PDBj:3vrw
PDBsum3vrw
PubMed22512505
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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