Structure of PDB 3vrv Chain A

Receptor sequence
>3vrvA (length=237) Species: 10116 (Rattus norvegicus) [Search protein sequence]
KLSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRPLSMLPHLADLVSY
SIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMSW
DCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMAI
CIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQK
LADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFG
3D structure
PDB3vrv Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands
ChainA
Resolution1.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 Q255 K260 P412 E416 I56 K60 Q73 K78 P230 E234
BS02 YSD A Y143 L223 V230 S233 R270 S271 S274 W282 C284 V296 H301 H393 Y21 L41 V48 S51 R88 S89 S92 W100 C102 V114 H119 H211 MOAD: ic50=0.029nM
PDBbind-CN: -logKd/Ki=10.54,IC50=0.029nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:3vrv, PDBe:3vrv, PDBj:3vrv
PDBsum3vrv
PubMed22512505
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

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