Structure of PDB 3vrt Chain A

Receptor sequence
>3vrtA (length=238) Species: 10116 (Rattus norvegicus) [Search protein sequence]
LSEEQQHIIAILLDAHHKTYDPTYADFRDFRPPVRMSPLSMLPHLADLVS
YSIQKVIGFAKMIPGFRDLTSDDQIVLLKSSAIEVIMLRSNQSFTMDDMS
WDCGSQDYKYDVTDVSKAGHTLELIEPLIKFQVGLKKLNLHEEEHVLLMA
ICIVSPDRPGVQDAKLVEAIQDRLSNTLQTYIRCRHPPPGSHQLYAKMIQ
KLADLRSLNEEHSKQYRSLSFQPENSMKLTPLVLEVFG
3D structure
PDB3vrt Butyl pocket formation in the vitamin d receptor strongly affects the agonistic or antagonistic behavior of ligands
ChainA
Resolution2.4 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A I238 K242 I256 K260 P412 E416 I57 K61 I75 K79 P231 E235
BS02 YS2 A Y143 S233 I264 R270 S271 S274 W282 C284 V296 H393 Y20 S52 I83 R89 S90 S93 W101 C103 V115 H212 MOAD: ic50=2.7nM
PDBbind-CN: -logKd/Ki=8.57,IC50=2.7nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3vrt, PDBe:3vrt, PDBj:3vrt
PDBsum3vrt
PubMed22512505
UniProtP13053|VDR_RAT Vitamin D3 receptor (Gene Name=Vdr)

[Back to BioLiP]