Structure of PDB 3vqt Chain A

Receptor sequence

>3vqtA (length=495) Species: 883 (Nitratidesulfovibrio vulgaris str. 'Miyazaki F')

MSSRLEREAARRRTFAIISHPDAGKTTLTEKLLLFGGAIQMAGSVKARVT
TSVMQFPYRDRVVNLLDTPGHQDFSEDTYRVLTAVDSALVVIDAAKGVEA
QTRKLMDVCRMRATPVMTFVNKMDREALHPLDVMADIEQHLQIECAPMTW
PIGMGSSFKGTYDLLHKQLHLFSQSGIVIHGADDPQLDEYLGDQAEQLRM
DLALLEEAGTPFDEERYLKGELTPVFFGSAINNFGVREMLDMFVEFAPGP
QPRPAATRVVEPGEEAFTGVVFKIQANRMAFLRICSGTFTRGMRLKHHRT
GKDVTVANATIFMAQDRTGVEEAFPGDIIGIPNHGTIKIGDTFTESKEVL
KFVGIPNFAPEHFRRVRLKNPLKAKQLQKGLEQLAEEGAVQLFRPLVNND
YILGAVGVLQFDVIVARLADEYGVDAVYEGVSTHTARWVYCEDKKIFADF
QDYHRGELAVDAEGALAYLAPNPWRLESAMERYPKVEFRTTREIS

3D structure

• PDB: 3vqt Crystal structure analysis of the translation factor RF3 (release factor 3)
• Chain: A
• Resolution: 1.8 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): D22
• Catalytic site (residue number reindexed from 1): D22

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	GDP	A	D22 G24 K25 T26 T27 H91 N141 K142 D144 R145 S256 I258	D22 G24 K25 T26 T27 H71 N121 K122 D124 R125 S229 I231

Gene Ontology

Molecular Function

• GO:0003924 GTPase activity
• GO:0005525 GTP binding
• GO:0016149 translation release factor activity, codon specific
• GO:0016150 translation release factor activity, codon nonspecific

Biological Process

• GO:0006412 translation
• GO:0006415 translational termination
• GO:0006449 regulation of translational termination

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:3vqt, PDBe:3vqt, PDBj:3vqt
• PDBsum: 3vqt
• PubMed: 22975312
• UniProt: B8DIL5|RF3_NITV9 Peptide chain release factor 3 (Gene Name=prfC)