Structure of PDB 3vq2 Chain A

Receptor sequence
>3vq2A (length=581) Species: 10090 (Mus musculus) [Search protein sequence]
PCIEVVPNITYQCMDQKLSKVPDDIPSSTKNIDLSFNPLKILKSYSFSNF
SELQWLDLSRCEIETIEDKAWHGLHHLSNLILTGNPIQSFSPGSFSGLTS
LENLVAVETKLASLESFPIGQLITLKKLNVAHNFIHSCKLPAYFSNLTNL
VHVDLSYNYIQTITVNDLQFLRENPQVNLSLDMSLNPIDFIQDQAFQGIK
LHELTLRGNFNSSNIMKTCLQNLAGLHVHRLILGEFKDERNLEIFEPSIM
EGLCDVTIDEFRLTYTNDFSDDIVKFHCLANVSAMSLAGVSIKYLEDVPK
HFKWQSLSIIRCQLKQFPTLDLPFLKSLTLTMNKGSISFKKVALPSLSYL
DLSRNALSFSGCCSYSDLGTNSLRHLDLSFNGAIIMSANFMGLEELQHLD
FQHSTLKRVTEFSAFLSLEKLLYLDISYTNTKIDFDGIFLGLTSLNTLKM
AGNSFKDNTLSNVFANTTNLTFLDLSKCQLEQISWGVFDTLHRLQLLNMS
HNNLLFLDSSHYNQLYSLSTLDCSFNRIETSKGILQHFPKSLAFFNLTNN
SVACICEHQKFLQWVKEQKQFLVNVEQMTCA
3D structure
PDB3vq2 Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2
ChainA
Resolution2.48 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LP5 A S413 F438 S387 F412
Gene Ontology
Molecular Function
GO:0004888 transmembrane signaling receptor activity
Biological Process
GO:0002224 toll-like receptor signaling pathway
GO:0006955 immune response
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3vq2, PDBe:3vq2, PDBj:3vq2
PDBsum3vq2
PubMed22532668
UniProtQ9QUK6|TLR4_MOUSE Toll-like receptor 4 (Gene Name=Tlr4)

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