Structure of PDB 3vn4 Chain A

Receptor sequence
>3vn4A (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
DAQPGLYYSANEQCRVAFGPKAVACTFHLDMCQALSCHTDPLDQSSCSRL
LVPLLDGTECGVEKWCSKGRCRSLVELTPIAAVHGRWSSWGPRSPCSRSC
GGGVVTRRRQCNNPRPAFGGRACVGADLQAEMCNTQACEKTQLEFMSQQC
ARTDGQPLSFYHWGAAVSHSQGDALCRHMCRAIGESFIMKRGDSFLDGTR
CMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVWDRCQVCGGDNSTCSP
RKGSFTAGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVRIGGRYVVAG
KMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQEDADIQV
YRRYGEEYGNLTRPDITFTYFQPKP
3D structure
PDB3vn4 Crystal structures of the noncatalytic domains of ADAMTS13 reveal multiple discontinuous exosites for von Willebrand factor
ChainA
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.87: ADAMTS13 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FUC A S399 C400 S99 C100
BS02 BGC A R398 C400 C438 F445 Q448 R98 C100 C138 F145 Q148
BS03 BMA A R386 W387 R86 W87
Gene Ontology
Biological Process
GO:0030198 extracellular matrix organization

View graph for
Biological Process
External links
PDB RCSB:3vn4, PDBe:3vn4, PDBj:3vn4
PDBsum3vn4
PubMed23621748
UniProtQ76LX8|ATS13_HUMAN A disintegrin and metalloproteinase with thrombospondin motifs 13 (Gene Name=ADAMTS13)

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