Structure of PDB 3vn2 Chain A

Receptor sequence
>3vn2A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence]
ESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLM
MGEDKIQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVT
LLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEP
KFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQA
LELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLH
PLLQEIYKDLY
3D structure
PDB3vn2 Structural basis for telmisartan-mediated partial activation of PPAR gamma
ChainA
Resolution2.18 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A K301 L311 V315 L318 K319 L468 E471 K85 L95 V99 L102 K103 L252 E255
BS02 TLS A F282 C285 R288 S289 H323 I326 Y327 L330 I341 F360 F363 M364 H449 Y473 F66 C69 R72 S73 H107 I110 Y111 L114 I125 F144 F147 M148 H233 Y257 BindingDB: EC50=1520nM,IC50=12200nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Cellular Component
External links
PDB RCSB:3vn2, PDBe:3vn2, PDBj:3vn2
PDBsum3vn2
PubMed22357520
UniProtP37231|PPARG_HUMAN Peroxisome proliferator-activated receptor gamma (Gene Name=PPARG)

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