Structure of PDB 3vml Chain A

Receptor sequence
>3vmlA (length=363) Species: 43661,211586 [Search protein sequence]
SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDN
HGCPLPEATLKGCEAADAVLFGSVGGPKWEHLPPNDQPERGALLPLRGHF
ELFCNMRPAKLHPGLEHMSPLRSDISEKGFDILCVRELTGGIYFGKPKGR
QGEGENEEAFDTMRYSRKEIRRIAKIAFESAQGRRKKVTSVDKANVLACS
VLWREVVEEVAKDYPDVELEHIYIDNATMQLLRRPNEFDVMLCSNLFGDI
VSDEIAMLTGSMGLLASISMNSQGFGMYEPAGGSAPDIAGQGIANPVAQI
LSAALLLRHSLKLEDAALAIEAAVSKALNSGYLTGELLSSDQRHKAKTTV
QMGDFIADAVKAG
3D structure
PDB3vml Structure analysis of chimeric 3-isopropylmalate dehydrogenase between the obligate piezophile Shewanella benthica DB21MT-2 and the nonpiezophile Shewanella oneidensis MR-1
ChainA
Resolution1.56 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y143 K193 D225 D249 D253
Catalytic site (residue number reindexed from 1) Y143 K193 D225 D249 D253
Enzyme Commision number 1.1.1.85: 3-isopropylmalate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IPM A R97 R136 Y143 D249 R97 R136 Y143 D249
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003862 3-isopropylmalate dehydrogenase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0051287 NAD binding
Biological Process
GO:0009098 L-leucine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3vml, PDBe:3vml, PDBj:3vml
PDBsum3vml
PubMed
UniProtD2YZL2;
Q8E9N3|LEU3_SHEON 3-isopropylmalate dehydrogenase (Gene Name=leuB)

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