Structure of PDB 3vkz Chain A

Receptor sequence
>3vkzA (length=364) Species: 211586 (Shewanella oneidensis MR-1) [Search protein sequence]
SSYQIAVLAGDGIGPEVMAEARKVLKAVEARFGLNIEYTEYDVGGIAIDN
HGCPLPEATLKGCEAADAILFGSVGGPKWEKLPPNEQPERGALLPLRGHF
ELFCNLRPAKLHDGLEHMSPLRSDISARGFDVLCVRELTGGIYFGKPKGR
QGEGESEEAFDTMRYSRREISRIARIAFEAARGRRKKVTSVDKANVLACS
VLWRQVVEEVAVDFPDVELEHIYIDNATMQLLRRPDEFDVMLCSNLFGDI
LSDEIAMLTGSMGLLSSASMNSTGFGLFEPAGGSAPDIAGKGIANPIAQI
LSAALMLRHSLKQEEAASAIERAVTKALNSGYLTGELLSSDQRHKAKTTV
QMGDFIADAVKAGV
3D structure
PDB3vkz High-pressure-induced water penetration into 3-isopropylmalate dehydrogenase
ChainA
Resolution1.84 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Y143 K193 D225 D249 D253
Catalytic site (residue number reindexed from 1) Y143 K193 D225 D249 D253
Enzyme Commision number 1.1.1.85: 3-isopropylmalate dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IPM A R97 R136 Y143 D249 R97 R136 Y143 D249
BS02 CA A D249 D253 D249 D253
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003862 3-isopropylmalate dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GO:0046872 metal ion binding
GO:0051287 NAD binding
Biological Process
GO:0009098 L-leucine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3vkz, PDBe:3vkz, PDBj:3vkz
PDBsum3vkz
PubMed22349232
UniProtQ8E9N3|LEU3_SHEON 3-isopropylmalate dehydrogenase (Gene Name=leuB)

[Back to BioLiP]