Structure of PDB 3vhv Chain A

Receptor sequence
>3vhvA (length=255) Species: 9606 (Homo sapiens) [Search protein sequence]
GSLSTISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAG
KQMIQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNS
QFLYFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKV
LLLLSTIPKDGLKSQAAFEEMRTNYIKELRKMVTKGQSWQRFYQLTKLLD
SMHDLVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNVKPL
YFHRK
3D structure
PDB3vhv Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists
ChainA
Resolution1.35 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 LD1 A N770 Q776 M807 L810 S811 L814 F829 M845 M852 L938 F941 C942 T945 N46 Q52 M83 L86 S87 L90 F105 M121 M128 L209 F212 C213 T216 MOAD: ic50=510nM
PDBbind-CN: -logKd/Ki=6.29,IC50=510nM
BindingDB: IC50=510nM
BS02 LD2 A A844 M845 E847 L848 F941 L952 A120 M121 E123 L124 F212 L223
External links
PDB RCSB:3vhv, PDBe:3vhv, PDBj:3vhv
PDBsum3vhv
PubMed22074142
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

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