Structure of PDB 3vhu Chain A

Receptor sequence
>3vhuA (length=249) Species: 9606 (Homo sapiens) [Search protein sequence]
STISRALTPSPVMVLENIEPEIVYAGYDSSKPDTAENLLSTLNRLAGKQM
IQVVKWAKVLPGFKNLPLEDQITLIQYSWMSLLSFALSWRSYKHTNSQFL
YFAPDLVFNEEKMHQSAMYELCQGMHQISLQFVRLQLTFEEYTIMKVLLL
LSTIPKDGLKSQAAFEEMRTNYIKELRKMVTGQSWQRFYQLTKLLDSMHD
LVSDLLEFCFYTFRESHALKVEFPAMLVEIISDQLPKVESGNAKPLYFH
3D structure
PDB3vhu Identification of Benzoxazin-3-one Derivatives as Novel, Potent, and Selective Nonsteroidal Mineralocorticoid Receptor Antagonists
ChainA
Resolution2.11 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SNL A L766 L769 N770 Q776 M807 L810 F829 M845 M852 L938 C942 T945 F956 L39 L42 N43 Q49 M80 L83 F102 M118 M125 L205 C209 T212 F223 MOAD: ic50=49nM
PDBbind-CN: -logKd/Ki=7.31,IC50=49nM
BindingDB: IC50=11nM,Ki=2.323nM
External links
PDB RCSB:3vhu, PDBe:3vhu, PDBj:3vhu
PDBsum3vhu
PubMed22074142
UniProtP08235|MCR_HUMAN Mineralocorticoid receptor (Gene Name=NR3C2)

[Back to BioLiP]