Structure of PDB 3vfq Chain A

Receptor sequence
>3vfqA (length=375) Species: 9606 (Homo sapiens) [Search protein sequence]
KCFSRTVLAPGVVLIVQQGDLARLPVDVVVNASNEDLKHYGGLAAALSKA
AGPELQADCDQIVKREGRLLPGNATISKAGKLPYHHVIHAVGPRWSGYEA
PRCVYLLRRAVQLSLCLAEKYKYRSIAIPAISSGVFGFPLGRCVETIVSA
IKENFQFKKDGHCLKEIYLVDVSEKTVEAFAEAVKTVFKGSLVSPGGLQM
LLVKEGVQNAKTDVVVNSVPLDLVLSRGPLSKSLLEKAGPELQEELDTVG
QGVAVSMGTVLKTSSWNLDCRYVLHVVAPEWRNGSTSSLKIMEDIIRECM
EITESLSLKSIAFPAIGTGNLGFPKNIFAELIISEVFKFSSKNQLKTLQE
VHFLLHPSDHENIQAFSDEFARRAN
3D structure
PDB3vfq Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains.
ChainA
Resolution2.8 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.4.2.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AR6 A G1022 V1023 S1034 P1036 G1044 P1045 L1046 S1049 A1131 G1133 T1134 G1135 N1136 L1137 H1172 D1175 G206 V207 S218 P220 G228 P229 L230 S233 A315 G317 T318 G319 N320 L321 H356 D359 PDBbind-CN: -logKd/Ki=5.19,Kd=6.4uM
External links
PDB RCSB:3vfq, PDBe:3vfq, PDBj:3vfq
PDBsum3vfq
PubMed23473667
UniProtQ460N5|PAR14_HUMAN Protein mono-ADP-ribosyltransferase PARP14 (Gene Name=PARP14)

[Back to BioLiP]