Structure of PDB 3vc1 Chain A

Receptor sequence
>3vc1A (length=277) Species: 100226 (Streptomyces coelicolor A3(2)) [Search protein sequence]
APATPYQEDIARYWNNEARPVNLRLGDVDGLYHHHYGIGPVDRAALGDPE
HSEYEKKVIAELHRLESAQAEFLMDHLGQAGPDDTLVDAGCGRGGSMVMA
HRRFGSRVEGVTLSAAQADFGNRRARELRIDDHVRSRVCNMLDTPFDKGA
VTASWNNESTMYVDLHDLFSEHSRFLKVGGRYVTITGCWNPRYGQPSKWV
SQINAHFECNIHSRREYLRAMADNRLVPHTIVDLTPDTLPYWELRATSSL
VTGIEKAFIESYRDGSFQYVLIAADRV
3D structure
PDB3vc1 Structure of Geranyl Diphosphate C-Methyltransferase from Streptomyces coelicolor and Implications for the Mechanism of Isoprenoid Modification.
ChainA
Resolution1.82 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.255: geranyl diphosphate 2-C-methyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SAH A Q22 W29 H48 H49 H50 G105 G107 T127 L128 Q132 C154 N155 M156 N172 E173 Y177 Q7 W14 H33 H34 H35 G90 G92 T112 L113 Q117 C139 N140 M141 N157 E158 Y162
BS02 GST A W29 R34 V36 N37 H49 Y51 M176 G202 F222 R260 W14 R19 V21 N22 H34 Y36 M161 G187 F207 R245
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0008168 methyltransferase activity
GO:0008169 C-methyltransferase activity
GO:0008757 S-adenosylmethionine-dependent methyltransferase activity
GO:1904047 S-adenosyl-L-methionine binding
Biological Process
GO:0032259 methylation
GO:0042214 terpene metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:3vc1, PDBe:3vc1, PDBj:3vc1
PDBsum3vc1
PubMed22455498
UniProtQ9F1Y5|GPPMT_STRCO Geranyl diphosphate 2-C-methyltransferase (Gene Name=SCO7701)

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