Structure of PDB 3var Chain A

Receptor sequence
>3varA (length=414) Species: 9913 (Bos taurus) [Search protein sequence]
GRARKEAVQAAARELLKFVNRSPSPFHAVAECRSRLLQAGFHELKETESW
DIKPESKYFLTRNSSTIIAFAVGGQYVPGNGFSLIGAHTDSPCLRVKRSQ
VGFQQVGVETYGGGIWSTWFDRDLTLAGRVIVEQRLVHVDRPILRIPHLA
IHLMEMHLVPILATSIQEELEKSVLTSLLCAHLGLSPEDILEMELCLADT
QPAVLGGAYEEFIFAPRLDNLHSCFCALQALIDSCSAPASLAADPHVRMI
ALYDNEEVGSESAQGAQSLLTELVLRRISASPQHLTAFEEAIPKSYMISA
DMAHAVHPNYLRPLFHKGPVIKVNSKQRYASNAVSEALIREVASSVGVPL
QDLTTIGPILASRLGLRVLDLGSPQLAMHSIRETACTTGVLQTITLFKGF
FELFPSLSRSLLVD
3D structure
PDB3var Insights into substrate specificity and metal activation of Mammalian tetrahedral aspartyl aminopeptidase.
ChainA
Resolution2.25 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.11.21: aspartyl aminopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN A H115 D285 D367 H88 D219 D301
BS02 ZN A D285 E323 H461 D219 E257 H379
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3var, PDBe:3var, PDBj:3var
PDBsum3var
PubMed22356908
UniProtQ2HJH1|DNPEP_BOVIN Aspartyl aminopeptidase (Gene Name=DNPEP)

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