Structure of PDB 3v9j Chain A

Receptor sequence
>3v9jA (length=544) Species: 10090 (Mus musculus) [Search protein sequence]
HMLRWKHTSSLKVANEPILAFSQGSPERDALQKALKDLKGQTEAIPCVVG
DEEVWTSDIQYQLSPFNHAHKVAKFCYADKALLNRAIDAALAARKEWDLK
PMADRAQVFLKAADMLSGPRRAEVLAKTMVGQGKTVIQAEIDAAAELIDF
FRFNAKFAVELEGEQPISVPPSTNHTVYRGLEGFVAAISPFNFTAIGGNL
AGAPALMGNVVLWKPSDTAMLASYAVYRILREAGLPPNIIQFVPADGPTF
GDTVTSSEHLCGINFTGSVPTFKHLWRQVAQNLDRFRTFPRLAGECGGKN
FHFVHSSADVDSVVSGTLRSAFEYGGQKCSACSRLYVPKSLWPQIKGRLL
EEHSRIKVGDPAEDFGTFFSAVIDAKAFARIKKWLEHARSSPSLSILAGG
QCNESVGYYVEPCIIESKDPQEPIMKEEIFGPVLTVYVYPDDKYRETLKL
VDSTTSYGLTGAVFAQDKAIVQEATRMLRNAAGNFYINDKSTGSVVGQQP
FGGARASGTNDKPGGPHYILRWTSPQVIKETHKPLGDWRYSYMQ
3D structure
PDB3v9j The Three-Dimensional Structural Basis of Type II Hyperprolinemia.
ChainA
Resolution1.299 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N211 K233 E314 C348 E447 P532
Catalytic site (residue number reindexed from 1) N192 K214 E295 C329 E428 P513
Enzyme Commision number 1.2.1.88: L-glutamate gamma-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 SO4 A S349 G512 S513 F520 S330 G493 S494 F501
BS02 SO4 A K233 S235 D236 K214 S216 D217
Gene Ontology
Molecular Function
GO:0003842 1-pyrroline-5-carboxylate dehydrogenase activity
GO:0004029 aldehyde dehydrogenase (NAD+) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0042802 identical protein binding
Biological Process
GO:0006560 proline metabolic process
GO:0010133 proline catabolic process to glutamate
Cellular Component
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3v9j, PDBe:3v9j, PDBj:3v9j
PDBsum3v9j
PubMed22516612
UniProtQ8CHT0|AL4A1_MOUSE Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial (Gene Name=Aldh4a1)

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