Structure of PDB 3v3v Chain A

Receptor sequence
>3v3vA (length=351) Species: 9606 (Homo sapiens) [Search protein sequence]
DNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKK
LSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYI
VMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSN
IVVKSDCTLKILDFGLARTAGTSPEVVTRYYRAPEVILGMGYKENVDIWS
VGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMKKLQPTVRTYV
ENRPKYAGYSFEKLFPDVLFPADSEHLKASQARDLLSKMLVIDASKRISV
DEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMD
L
3D structure
PDB3v3v Structural and Functional Analysis of the Natural JNK1 Inhibitor Quercetagetin.
ChainA
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) D151 K153 N156 D169 T188
Catalytic site (residue number reindexed from 1) D145 K147 N150 D163 T178
Enzyme Commision number 2.7.11.24: mitogen-activated protein kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide A M121 R127 Y130 S161 D162 C163 W324 E329 M115 R121 Y124 S155 D156 C157 W312 E317
BS02 MYU A K55 E73 M108 L110 M111 A113 V158 L168 D169 K49 E67 M102 L104 M105 A107 V152 L162 D163 PDBbind-CN: -logKd/Ki=5.34,IC50=4.6uM
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:3v3v, PDBe:3v3v, PDBj:3v3v
PDBsum3v3v
PubMed23142567
UniProtP45983|MK08_HUMAN Mitogen-activated protein kinase 8 (Gene Name=MAPK8)

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