Structure of PDB 3v3q Chain A

Receptor sequence
>3v3qA (length=237) Species: 9606 (Homo sapiens) [Search protein sequence]
DAPANLLTSLVRAHLDSGPSTAKLDYSKFQELVLPHFGKEDAGDVQQFYD
LLSGSLEVIRKWAEKIPGFAELSPADQDLLLESAFLELFILRLAYRSKPG
EGKLIFCSGLVLHRLQCARGFGDWIDSILAFSRSLHSLLVDVPAFACLSA
LVLITDRHGLQEPRRVEELQNRIASCLKEHVAAVAPASCLSRLLGKLPEL
RTLCTQGLQRIFYLKLEDLVPPPPIIDKIFMDTLPFL
3D structure
PDB3v3q The orphan nuclear receptor Nur77 regulates LKB1 localization and activates AMPK
ChainA
Resolution2.22 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TMY A E109 S110 A111 F112 L113 E114 R232 C235 L239 I260 T264 E82 S83 A84 F85 L86 E87 R201 C204 L208 I229 T233 PDBbind-CN: -logKd/Ki=6.60,Kd=0.25uM
BS02 TMY A H41 L42 P46 Y122 R123 L162 H163 L166 V167 V169 H14 L15 P19 Y95 R96 L135 H136 L139 V140 V142 PDBbind-CN: -logKd/Ki=6.60,Kd=0.25uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3v3q, PDBe:3v3q, PDBj:3v3q
PDBsum3v3q
PubMed22983157
UniProtP22736|NR4A1_HUMAN Nuclear receptor subfamily 4immunitygroup A member 1 (Gene Name=NR4A1)

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