Structure of PDB 3v3o Chain A

Receptor sequence
>3v3oA (length=368) Species: 818 (Bacteroides thetaiotaomicron) [Search protein sequence]
LLSDKNVAIIGGGPVGLTMAKLLQQNGIDVSVYERDNDREARIFGGTLDL
HKGSGQEAMKKAGLLQTYYDLALPMGVNIADKKGNILSTKNVKPENRFDN
PEINRNDLRAILLNSLENDTVIWDRKLVMLEPGKKKWTLTFENKPSETAD
LVILANGGMSKVRKFVTDTEVEETGTFNIQADIHQPEINCPGFFQLCNGN
RLMASHQGNLLFANPNNNGALHFGISFKTPDEWKNVDFQNRNSVVDFLLK
KFSDWDERYKELIHATLSFVGLATRIFPLEKPWKSKRPLPITMIGDAAHL
MPPFAGQGVNSGLVDALILSDNLADGKFNSIEEAVKNYEQQMFIYGKEAQ
EESTQNEIEMFKPDFTFQ
3D structure
PDB3v3o Crystal structure of TetX2 T280A: an adaptive mutant in complex with tigecycline
ChainA
Resolution2.9 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 1.14.13.231: tetracycline 11a-monooxygenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD A G23 G24 G25 P26 V27 E46 R47 L60 R117 L139 N168 G169 Q192 D311 P318 G323 V324 G11 G12 G13 P14 V15 E34 R35 L48 R105 L127 N156 G157 Q180 D296 P303 G308 V309
BS02 T1C A T59 R213 F224 G236 F319 A320 G321 M375 F382 Q383 T47 R201 F212 G224 F304 A305 G306 M360 F367 Q368
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004497 monooxygenase activity
GO:0071949 FAD binding
Biological Process
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:3v3o, PDBe:3v3o, PDBj:3v3o
PDBsum3v3o
PubMed
UniProtQ93L51|TETX_BACT4 Flavin-dependent monooxygenase (Gene Name=tetX2)

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